ARF6

Across TCGA patient cohorts, ARF6 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,026 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ARF6-associated proteins across cancer lineages are GNPNAT1, MTHFD1, and MAP4K5. Each is linked with ARF6 in more than 5 cancer types. Because this analysis shows association rather than direction, both ARF6-to-partner and partner-to-ARF6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARF6 versus GNPNAT1 in LSCC, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ARF6→partner) and Y-score (partner→ARF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GNPNAT1 →	+0.582	+0.668	<.001	<.001	3	6
OV	MTHFD1 →	+0.299	+0.497	.009	<.001	3	6
HNSC	MAP4K5 →	+0.337	+0.910	.004	.009	3	6
GBM	PURA →	-0.443	-0.383	<.001	<.001	3	5
GBM	WDHD1 →	+0.665	+0.408	<.001	<.001	3	5
LSCC	NCAPG →	+0.477	+0.524	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,026 associations by consensus.

ARF6 vs GNPNAT1 — LSCC

Explore this scatter interactively →