ARF6

Across TCGA patient cohorts, ARF6 mutation is significantly associated with the RNA expression of many other genes, with 1,718 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARF6-associated genes across cancer lineages are RNA5SP326, RPL35P8, and SNRPGP7. Each is linked with ARF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARF6-to-partner and partner-to-ARF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP326 grouped by ARF6-low versus ARF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARF6→partner) and Y-score (partner→ARF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP326 →	+0.488	+2.449	<.001	.007	3	2
UCEC	RPL35P8 →	+0.199	+1.876	<.001	.001	3	2
UCEC	SNRPGP7 →	+0.156	+3.013	<.001	.001	3	2
COAD	RNA5SP109 →	+0.368	+6.149	<.001	<.001	3	2
CESC	RNU6-258P →	+0.195	+5.164	<.001	.002	3	2
CESC	RNU6-644P →	+0.306	+3.608	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,718 associations by consensus.

RNA5SP326 by ARF6 expression — UCEC

Explore this box plot interactively →