ARF6

Across TCGA cell cohorts, ARF6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,365 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ARF6-associated GO terms across cancer lineages are Dephosphorylation, Regulation of cytokinetic process, and Protein dephosphorylation. Each is linked with ARF6 in more than 9 cancer types. Because this analysis shows association rather than direction, both ARF6-to-partner and partner-to-ARF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dephosphorylation grouped by ARF6-low versus ARF6-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARF6→partner) and Y-score (partner→ARF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Dephosphorylation →	+0.062	+0.811	<.001	.003	3	10
LUNG_SCLC	Regulation of cytokinetic process →	+0.132	+0.622	<.001	.004	3	9
KIDNEY	Protein dephosphorylation →	+0.063	+0.726	.002	.004	2	10
STOMACH	Negative regulation of actin filament polymerization →	+0.121	+0.779	.002	.004	3	9
LUNG_SCLC	Regulation of mitotic cytokinetic process →	+0.132	+0.622	<.001	.004	3	9
LUNG_SCLC	Positive regulation of mitotic cytokinetic process →	+0.132	+0.622	<.001	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,365 associations by consensus.

Dephosphorylation by ARF6 expression — LIVER

Explore this box plot interactively →