ARF4

Across TCGA patient cohorts, ARF4 mutation is significantly associated with the RNA expression of many other genes, with 1,311 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARF4-associated genes across cancer lineages are MDH1P2, RPL12P40, and MTA2. Each is linked with ARF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARF4-to-partner and partner-to-ARF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDH1P2 grouped by ARF4-low versus ARF4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARF4→partner) and Y-score (partner→ARF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MDH1P2 →	+0.183	+4.792	<.001	.003	3	2
SKCM	RPL12P40 →	+0.120	+5.594	<.001	.004	3	2
UCEC	MTA2 →	+0.482	+2.641	.001	.005	3	1
UCEC	CPSF7 →	+0.451	+3.475	.002	.002	3	1
UCEC	MAT1A →	-1.083	-2.700	.001	.006	3	1
UCEC	GPATCH11 →	+0.526	+2.711	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,311 associations by consensus.

MDH1P2 by ARF4 expression — COAD

Explore this box plot interactively →