ARF4

Across TCGA cell cohorts, ARF4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,116 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ARF4-associated GO terms across cancer lineages are Regulation of protein exit from endoplasmic reticulum, Positive regulation of protein exit from endoplasmic reticulum, and COPII-coated vesicle cargo loading. Each is linked with ARF4 in more than 17 cancer types. Because this analysis shows association rather than direction, both ARF4-to-partner and partner-to-ARF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein exit from endoplasmic reticulum grouped by ARF4-low versus ARF4-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARF4→partner) and Y-score (partner→ARF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of protein exit from endoplasmic reticulum →	+0.127	+0.725	<.001	<.001	3	18
LIVER	Positive regulation of protein exit from endoplasmic reticulum →	+0.141	+0.683	<.001	.001	3	18
BONE	COPII-coated vesicle cargo loading →	+0.111	+1.064	<.001	<.001	3	16
BONE	Protein localization to early endosome →	+0.210	+1.055	<.001	<.001	3	16
STOMACH	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.094	+1.039	<.001	<.001	3	14
BLOOD_Myeloma	Cytosol to Golgi apparatus transport →	+0.116	+0.789	.005	.005	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,116 associations by consensus.

Regulation of protein exit from endoplasmic reticulum by ARF4 expression — LIVER

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