ARF3

Across TCGA patient cohorts, ARF3 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARF3-associated genes across cancer lineages are Heregulin, MEK1, and Tuberin_pT1462. Each is linked with ARF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARF3-to-partner and partner-to-ARF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by ARF3-low versus ARF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARF3→partner) and Y-score (partner→ARF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.161	-3.321	.013	.010	3	1
UCEC	MEK1 →	+0.396	+2.999	.038	.035	3	1
UCEC	Tuberin_pT1462 →	+0.377	+2.179	.001	.034	3	1
UCEC	Bid →	-0.173	-3.000	.005	.036	3	1
UCEC	Tuberin →	+0.427	+2.817	.002	.036	2	1
UCEC	p62 Lck ligand →	+0.475	+3.321	.005	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Heregulin by ARF3 expression — UCEC

Explore this box plot interactively →