ARF3

Across TCGA cell cohorts, ARF3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARF3-associated genes across cancer lineages are ZNF831, TAFA1, and SLC15A5. Each is linked with ARF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARF3-to-partner and partner-to-ARF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF831 grouped by ARF3-low versus ARF3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARF3→partner) and Y-score (partner→ARF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF831 →	+0.018	+4.273	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.410	+4.273	<.001	.006	3	1
LARGE_INTESTINE	SLC15A5 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CENPVL1 →	+0.227	+4.095	<.001	.009	3	1
LARGE_INTESTINE	SCT →	+0.220	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ZNF831 by ARF3 expression — LARGE_INTESTINE

Explore this box plot interactively →