ARF1

Across TCGA patient cohorts, ARF1 mutation is significantly associated with the RNA expression of many other genes, with 3,469 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARF1-associated genes across cancer lineages are HNRNPMP2, GUSBP17, and RNU6-1213P. Each is linked with ARF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARF1-to-partner and partner-to-ARF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HNRNPMP2 grouped by ARF1-low versus ARF1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARF1→partner) and Y-score (partner→ARF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	HNRNPMP2 →	+0.071	+4.757	<.001	.004	3	2
UCEC	GUSBP17 →	+0.045	+2.943	<.001	.001	3	2
UCEC	RNU6-1213P →	+0.136	+3.002	<.001	.006	3	2
BLCA	MIR1225 →	+0.468	+7.640	<.001	.009	3	2
LUSC	MIR4713 →	+0.523	+6.438	<.001	.001	3	2
BRCA	MIR6853 →	+0.459	+9.057	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,469 associations by consensus.

HNRNPMP2 by ARF1 expression — CESC

Explore this box plot interactively →