ARF1

Across TCGA cell cohorts, ARF1 mutation is significantly associated with the mutation status of many other genes, with 84 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ARF1-associated genes across cancer lineages are EPDR1, GPT, and FOXR1. Each is linked with ARF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARF1-to-partner and partner-to-ARF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPDR1 grouped by ARF1-low versus ARF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARF1→partner) and Y-score (partner→ARF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EPDR1 →	+5.523	+5.523	.003	.003	1	2
SKIN	GPT →	+4.392	+4.392	.009	.009	1	2
SKIN	FOXR1 →	+5.392	+4.824	.004	.004	1	2
SKIN	SPNS3 →	+4.392	+4.392	.009	.009	1	2
SKIN	CXCR3 →	+4.392	+4.392	.009	.009	1	2
SKIN	ZDHHC9 →	+4.392	+4.392	.009	.009	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

EPDR1 by ARF1 expression — LARGE_INTESTINE

Explore this box plot interactively →