AREL1

Across TCGA patient cohorts, AREL1 mutation is significantly associated with the RNA expression of many other genes, with 4,486 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AREL1-associated genes across cancer lineages are MYO19, C22orf46, and BTBD6. Each is linked with AREL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AREL1-to-partner and partner-to-AREL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO19 grouped by AREL1-low versus AREL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AREL1→partner) and Y-score (partner→AREL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYO19 →	+0.496	+2.129	<.001	<.001	3	3
UCEC	C22orf46 →	+0.330	+2.021	<.001	.001	3	3
UCEC	BTBD6 →	+0.300	+1.562	.001	<.001	3	3
UCEC	TMEM222 →	+0.260	+2.163	.001	<.001	3	3
UCEC	ZKSCAN5 →	+0.280	+1.754	<.001	<.001	3	3
SKCM	MAPK1 →	+0.751	+3.478	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,486 associations by consensus.

MYO19 by AREL1 expression — UCEC

Explore this box plot interactively →