AREL1

Across TCGA patient cohorts, AREL1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AREL1-associated genes across cancer lineages are MEK1, Bcl-2, and Rab25. Each is linked with AREL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AREL1-to-partner and partner-to-AREL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by AREL1-low versus AREL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AREL1→partner) and Y-score (partner→AREL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.397	+2.050	<.001	<.001	3	3
UCEC	Bcl-2 →	-0.245	-1.395	.017	.043	3	3
UCEC	Rab25 →	-0.227	-1.874	.021	.049	3	2
UCEC	Annexin-1 →	+0.657	+2.392	<.001	<.001	3	2
UCEC	TIGAR →	+0.094	+1.405	.039	.005	3	2
UCEC	ATM →	-0.487	-1.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

MEK1 by AREL1 expression — UCEC

Explore this box plot interactively →