AREG

Across TCGA patient cohorts, AREG protein abundance is significantly associated with the RNA expression of many other genes, with 2,562 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AREG-associated genes across cancer lineages are EREG, EIF3B, and ARPC5L. Each is linked with AREG in more than 2 cancer types. Because this analysis shows association rather than direction, both AREG-to-partner and partner-to-AREG results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AREG versus EREG in COAD, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AREG→partner) and Y-score (partner→AREG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EREG →	+2.218	+1.272	<.001	<.001	3	3
LUAD	EIF3B →	+0.840	+0.923	.001	.004	3	2
LUAD	ARPC5L →	+0.496	+1.128	.007	.001	3	2
LUAD	FOSL1 →	+1.568	+1.126	.002	.001	3	2
LUAD	MAF1 →	+0.951	+1.030	.008	.003	3	2
COAD	C8orf33 →	+0.837	+1.199	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,562 associations by consensus.

AREG vs EREG — COAD

Explore this scatter interactively →