AREG

Across TCGA patient cohorts, AREG mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible AREG-associated genes across cancer lineages are eEF2, MAPK_pT202_Y204, and PDCD4. Each is linked with AREG in more than 1 cancer types. Because this analysis shows association rather than direction, both AREG-to-partner and partner-to-AREG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by AREG-low versus AREG-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AREG→partner) and Y-score (partner→AREG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eEF2 →	+0.385	+2.459	.007	.018	3	1
SKCM	MAPK_pT202_Y204 →	-0.405	-2.321	.035	.033	3	1
SKCM	PDCD4 →	-0.400	-3.169	.022	.018	3	1
SKCM	53BP1 →	+0.354	+2.115	.029	.018	3	1
UCEC	MEK1 →	+0.540	+3.000	.010	.037	3	1
UCEC	Notch1 →	+0.167	+3.000	.040	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

eEF2 by AREG expression — SKCM

Explore this box plot interactively →