AREG

Across TCGA cell cohorts, AREG RNA expression is significantly associated with the go_rna of many other GO terms, with 3,427 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible AREG-associated GO terms across cancer lineages are Positive regulation of keratinocyte proliferation, Cellular response to external stimulus, and ERBB2-EGFR signaling pathway. Each is linked with AREG in more than 10 cancer types. Because this analysis shows association rather than direction, both AREG-to-partner and partner-to-AREG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of keratinocyte proliferation grouped by AREG-low versus AREG-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AREG→partner) and Y-score (partner→AREG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of keratinocyte proliferation →	+0.218	+3.446	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Cellular response to external stimulus →	+0.089	+3.472	.001	.002	3	11
OESOPHAGUS	ERBB2-EGFR signaling pathway →	+0.376	+2.908	.008	<.001	3	11
LARGE_INTESTINE	Positive regulation of bicellular tight junction assembly →	+0.205	+2.263	<.001	.001	3	11
URINARY_TRACT	Regulation of keratinocyte proliferation →	+0.166	+4.452	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Luteinizing hormone signaling pathway →	+1.602	+4.305	<.001	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,427 associations by consensus.

Positive regulation of keratinocyte proliferation by AREG expression — URINARY_TRACT

Explore this box plot interactively →