Across TCGA patient cohorts, ARC protein abundance is significantly associated with the RNA expression of many other genes, with 1,707 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ARC-associated genes across cancer lineages are PES1, CYTH4, and CARD10. Each is linked with ARC in more than 1 cancer types. Because this analysis shows association rather than direction, both ARC-to-partner and partner-to-ARC results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARC→partner) and Y-score (partner→ARC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PES1 →	+0.420	+0.525	<.001	<.001	3	1
GBM	CYTH4 →	-0.718	-0.475	.005	.001	3	1
GBM	CARD10 →	+0.407	+0.469	.001	<.001	3	1
GBM	SEZ6L →	+1.252	+0.355	.002	<.001	3	1
GBM	SRRD →	+0.340	+0.403	<.001	.002	3	1
GBM	PATZ1 →	+0.577	+0.403	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,707 associations by consensus.

Exploration

ARC survival (RNA) · tumor vs normal (RNA) · all ARC data types