Across TCGA patient cohorts, ARC mutation is significantly associated with the RNA expression of many other genes, with 1,109 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARC-associated genes across cancer lineages are HSPA4L, SMIM11P1, and FBXO25. Each is linked with ARC in more than 2 cancer types. Because this analysis shows association rather than direction, both ARC-to-partner and partner-to-ARC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARC→partner) and Y-score (partner→ARC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSPA4L →	+0.925	+2.243	<.001	.006	3	3
SKCM	SMIM11P1 →	+0.132	+3.242	<.001	.008	3	3
UCEC	FBXO25 →	+0.427	+3.533	.003	.002	3	3
CESC	KRTAP9-9 →	+0.053	+4.539	<.001	.008	3	2
UCEC	CENPU →	+0.731	+2.939	.003	<.001	3	2
UCEC	SLC25A4 →	+0.602	+3.609	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,109 associations by consensus.

Exploration

ARC survival (RNA) · tumor vs normal (RNA) · all ARC data types