Across TCGA cell cohorts, ARC mutation is significantly associated with the mutation status of many other genes, with 1,569 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARC-associated genes across cancer lineages are ADAM29, ZNF507, and DENND4A. Each is linked with ARC in more than 2 cancer types. Because this analysis shows association rather than direction, both ARC-to-partner and partner-to-ARC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARC→partner) and Y-score (partner→ARC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ADAM29 →	+3.339	+4.662	.003	.003	1	3
BLOOD_Leukemia	ZNF507 →	+3.870	+4.050	.002	.002	1	3
BLOOD_Leukemia	DENND4A →	+3.285	+3.662	.004	.004	1	3
LUNG_NSCLC_LUAD	VPS13A →	+2.754	+4.189	.008	.008	1	3
LUNG_SCLC	KLHL42 →	+4.502	+5.066	.007	.007	1	3
LARGE_INTESTINE	TAX1BP1 →	+2.536	+3.504	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,569 associations by consensus.

Exploration

ARC survival (RNA) · tumor vs normal (RNA) · all ARC data types