ARAP2

Across TCGA patient cohorts, ARAP2 mutation is significantly associated with the RNA expression of many other genes, with 5,432 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARAP2-associated genes across cancer lineages are PAMR1, GPR3, and GBGT1. Each is linked with ARAP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARAP2-to-partner and partner-to-ARAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAMR1 grouped by ARAP2-low versus ARAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARAP2→partner) and Y-score (partner→ARAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PAMR1 →	-0.572	-1.671	.008	<.001	3	4
SKCM	GPR3 →	+0.453	+2.208	.001	.001	3	4
LUAD	GBGT1 →	-0.472	-2.391	.005	.003	3	4
UCEC	CDCA8 →	+0.604	+1.595	<.001	<.001	3	4
UCEC	KPNA2 →	+0.437	+1.874	.004	<.001	3	4
UCEC	PRC1 →	+0.679	+1.584	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,432 associations by consensus.

PAMR1 by ARAP2 expression — UCEC

Explore this box plot interactively →