ARAP2

Across TCGA patient cohorts, ARAP2 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARAP2-associated genes across cancer lineages are ACC1, FASN, and ASNS. Each is linked with ARAP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARAP2-to-partner and partner-to-ARAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by ARAP2-low versus ARAP2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARAP2→partner) and Y-score (partner→ARAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ACC1 →	+0.367	+1.882	.026	.031	3	3
UCEC	FASN →	+0.224	+1.064	.033	.043	3	3
UCEC	ASNS →	+0.297	+1.263	.002	.016	3	3
COAD	Caspase-7-cleavedD198 →	+0.974	+2.824	.003	.034	3	3
UCEC	Caspase-8 →	-0.206	-1.502	.002	<.001	3	3
UCEC	4E-BP1 →	+0.328	+1.502	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

ACC1 by ARAP2 expression — COAD

Explore this box plot interactively →