AQR

Across TCGA pan-cancer cohorts, AQR mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated AQR data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher AQR mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AQR expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LSCC, and GBM are the cancer types where AQR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	IV	0.785	0.214	.006	15	view →
LSCC	DFS	Tertile	II,III,IV	0.874	0.565	.013	8	view →
GBM	OS	Quartile	All	0.541	0.237	.005	6	view →
HNSC	DFS	Quartile	III,IV	0.640	0.950	.007	4	view →
LUAD	OS	Median	All	0.722	0.924	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

AQR–PDAC (DFS)

Open the PDAC breakdown →