AQR

Across TCGA patient cohorts, AQR mutation is significantly associated with the RNA expression of many other genes, with 4,233 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AQR-associated genes across cancer lineages are SEC13, RAD51, and GTSE1. Each is linked with AQR in more than 3 cancer types. Because this analysis shows association rather than direction, both AQR-to-partner and partner-to-AQR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC13 grouped by AQR-low versus AQR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQR→partner) and Y-score (partner→AQR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC13 →	+0.400	+2.732	<.001	<.001	3	4
UCEC	RAD51 →	+0.807	+2.050	<.001	<.001	3	4
UCEC	GTSE1 →	+0.742	+1.912	<.001	<.001	3	4
UCEC	UBE2T →	+0.544	+1.712	<.001	<.001	3	4
UCEC	HJURP →	+0.523	+2.032	<.001	.001	3	4
UCEC	FANCD2 →	+0.467	+2.091	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,233 associations by consensus.

SEC13 by AQR expression — UCEC

Explore this box plot interactively →