AQR

Across TCGA cell cohorts, AQR mutation is significantly associated with the RNA expression of many other genes, with 1,190 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AQR-associated genes across cancer lineages are FAM160A1, HSP90AB1, and OR2B3. Each is linked with AQR in more than 1 cancer types. Because this analysis shows association rather than direction, both AQR-to-partner and partner-to-AQR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM160A1 grouped by AQR-low versus AQR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQR→partner) and Y-score (partner→AQR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM160A1 →	+0.894	+3.447	<.001	.001	3	2
LARGE_INTESTINE	HSP90AB1 →	+0.534	+3.169	.001	.009	3	2
LUNG_NSCLC_LUAD	OR2B3 →	+0.013	+3.813	<.001	.001	3	2
BLOOD_Leukemia	SCGB3A2 →	+0.082	+3.922	<.001	.002	3	2
PANCREAS	ZAN →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	C1orf87 →	+0.055	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,190 associations by consensus.

FAM160A1 by AQR expression — LARGE_INTESTINE

Explore this box plot interactively →