AQP9

Across TCGA patient cohorts, AQP9 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AQP9-associated genes across cancer lineages are 14-3-3_beta, FASN, and PDCD4. Each is linked with AQP9 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP9-to-partner and partner-to-AQP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by AQP9-low versus AQP9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP9→partner) and Y-score (partner→AQP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.092	-1.893	.022	.016	3	2
UCEC	FASN →	+0.417	+3.321	.008	.010	3	2
UCEC	PDCD4 →	-0.517	-1.906	.006	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.673	+2.604	.004	.005	3	2
UCEC	Cyclin-B1 →	+0.638	+1.906	.004	.016	3	2
SKCM	ASNS →	+0.445	+3.000	.026	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

14-3-3_beta by AQP9 expression — UCEC

Explore this box plot interactively →