AQP9

Across TCGA cell cohorts, AQP9 RNA expression is significantly associated with the go_rna of many other GO terms, with 972 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible AQP9-associated GO terms across cancer lineages are Regulation of RNA splicing, Cellular response to nutrient levels, and Response to endoplasmic reticulum stress. Each is linked with AQP9 in more than 6 cancer types. Because this analysis shows association rather than direction, both AQP9-to-partner and partner-to-AQP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA splicing grouped by AQP9-low versus AQP9-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP9→partner) and Y-score (partner→AQP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of RNA splicing →	+0.058	+0.039	<.001	.002	3	6
BLOOD_Lymphoma	Cellular response to nutrient levels →	+0.034	+1.186	<.001	.007	3	5
LARGE_INTESTINE	Response to endoplasmic reticulum stress →	+0.035	+0.019	.002	.009	1	7
OESOPHAGUS	SRP-dependent cotranslational protein targeting to membrane →	+0.105	+0.020	.006	.006	3	4
LARGE_INTESTINE	Regulation of cell-substrate junction organization →	+0.056	+0.024	.001	.009	3	4
BLOOD_Lymphoma	Regulation of tumor necrosis factor superfamily cytokine production →	+0.054	+1.459	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 972 associations by consensus.

Regulation of RNA splicing by AQP9 expression — LARGE_INTESTINE

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