AQP8

Across TCGA pan-cancer cohorts, AQP8 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of AQP8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where AQP8 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types AQP8 is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

COAD and PDAC are the cancer types where AQP8 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AQP8 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.650	<.001	9	view →
PDAC	Female	All	−3.287	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

AQP8–COAD

Open the COAD breakdown →