AQP7

Across TCGA patient cohorts, AQP7 mutation is significantly associated with the RNA expression of many other genes, with 1,389 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AQP7-associated genes across cancer lineages are TUBGCP5, CHAF1B, and BAP1. Each is linked with AQP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP7-to-partner and partner-to-AQP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBGCP5 grouped by AQP7-low versus AQP7-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP7→partner) and Y-score (partner→AQP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TUBGCP5 →	+0.654	+3.220	.005	.009	3	2
UCEC	CHAF1B →	+0.658	+2.823	.001	.001	3	2
UCEC	BAP1 →	+0.344	+3.419	.005	.004	3	2
UCEC	LRRC20 →	+0.826	+2.425	<.001	.002	3	2
UCEC	SLAMF7 →	+1.133	+2.914	<.001	.001	3	2
COAD	BPY2DP →	+0.233	+5.409	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,389 associations by consensus.

TUBGCP5 by AQP7 expression — SKCM

Explore this box plot interactively →