AQP6

Across TCGA patient cohorts, AQP6 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AQP6-associated genes across cancer lineages are c-Kit, Lck, and mTOR_pS2448. Each is linked with AQP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP6-to-partner and partner-to-AQP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by AQP6-low versus AQP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP6→partner) and Y-score (partner→AQP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Kit →	-0.201	-2.222	.042	.011	3	2
UCEC	Lck →	+0.200	+1.700	.018	.044	3	1
UCEC	mTOR_pS2448 →	-0.155	-3.302	.014	.010	3	1
UCEC	Notch1 →	+0.142	+2.009	.017	.017	3	1
UCEC	TFRC →	+0.601	+3.169	.007	.019	3	1
UCEC	ATM →	-0.468	-2.222	.015	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

c-Kit by AQP6 expression — UCEC

Explore this box plot interactively →