AQP4

Across TCGA patient cohorts, AQP4 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,644 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AQP4-associated proteins across cancer lineages are SORBS2_S259, BDH2, and DDAH1. Each is linked with AQP4 in more than 4 cancer types. Because this analysis shows association rather than direction, both AQP4-to-partner and partner-to-AQP4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AQP4 versus SORBS2_S259 in LSCC, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP4→partner) and Y-score (partner→AQP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SORBS2_S259 →	+0.690	+1.597	<.001	<.001	3	5
GBM	BDH2 →	+0.582	+1.470	<.001	<.001	3	5
HNSC	DDAH1 →	+0.614	+0.440	<.001	<.001	3	5
LSCC	DPYSL2 →	+0.373	+1.793	<.001	<.001	3	5
CCRCC	UTRN →	+0.288	+0.828	<.001	<.001	3	4
LSCC	PSMD2 →	-0.183	-1.465	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,644 associations by consensus.

AQP4 vs SORBS2_S259 — LSCC

Explore this scatter interactively →