AQP4

Across TCGA patient cohorts, AQP4 protein abundance is significantly associated with the RNA expression of many other genes, with 7,877 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AQP4-associated genes across cancer lineages are SEMA3G, PCDH17, and PTPRB. Each is linked with AQP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both AQP4-to-partner and partner-to-AQP4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AQP4 versus SEMA3G in GBM, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP4→partner) and Y-score (partner→AQP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEMA3G →	+0.564	+0.646	.005	.001	3	3
GBM	PCDH17 →	+0.737	+0.608	.003	.002	3	3
LSCC	PTPRB →	+0.645	+0.787	<.001	<.001	3	3
LSCC	PEBP4 →	+2.183	+0.937	<.001	<.001	3	3
LSCC	SLC19A3 →	+0.494	+0.669	<.001	<.001	3	3
GBM	TAL1 →	+0.791	+0.607	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,877 associations by consensus.

AQP4 vs SEMA3G — GBM

Explore this scatter interactively →