AQP4

Across TCGA patient cohorts, AQP4 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AQP4-associated genes across cancer lineages are Tuberin, ASNS, and eIF4E. Each is linked with AQP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP4-to-partner and partner-to-AQP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by AQP4-low versus AQP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP4→partner) and Y-score (partner→AQP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.350	+2.817	<.001	.001	3	2
UCEC	ASNS →	+0.498	+1.765	<.001	.014	3	2
UCEC	eIF4E →	+0.191	+2.169	.016	.003	3	1
UCEC	eIF4G →	+0.303	+2.321	.009	.034	3	1
UCEC	A-Raf_pS299 →	-0.134	-2.700	.002	.006	3	1
UCEC	FoxM1 →	+0.194	+1.765	.045	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Tuberin by AQP4 expression — UCEC

Explore this box plot interactively →