AQP4

Across TCGA cell cohorts, AQP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 772 significant associations in total. KIDNEY shows the largest number of these associations.

The most reproducible AQP4-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Golgi vesicle transport, and Protein localization to lysosome. Each is linked with AQP4 in more than 7 cancer types. Because this analysis shows association rather than direction, both AQP4-to-partner and partner-to-AQP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by AQP4-low versus AQP4-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP4→partner) and Y-score (partner→AQP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of syncytium formation by plasma membrane fusion →	+0.098	+0.543	.002	.004	2	8
OVARY	Golgi vesicle transport →	+0.052	+0.158	.001	.003	2	7
LUNG_NSCLC_LUAD	Protein localization to lysosome →	+0.043	+0.462	.001	.007	3	6
LUNG_SCLC	Golgi lumen acidification →	+0.090	+0.890	<.001	.003	3	5
OVARY	Peroxisome organization →	+0.060	+0.206	<.001	<.001	2	6
OVARY	Mitotic cytokinesis →	+0.066	+0.137	.003	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 772 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by AQP4 expression — KIDNEY

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