AQP4

Across TCGA cell cohorts, AQP4 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible AQP4-associated genes across cancer lineages are ZNF705G and OR2T4. Each is linked with AQP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP4-to-partner and partner-to-AQP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF705G grouped by AQP4-low versus AQP4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP4→partner) and Y-score (partner→AQP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF705G →	+0.011	+4.217	<.001	.001	3	1
SKIN	OR2T4 →	+0.026	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

ZNF705G by AQP4 expression — LARGE_INTESTINE

Explore this box plot interactively →