AQP3

Across TCGA patient cohorts, AQP3 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AQP3-associated genes across cancer lineages are p38-MAPK_pT180_Y182, ACC1, and MEK1. Each is linked with AQP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP3-to-partner and partner-to-AQP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by AQP3-low versus AQP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP3→partner) and Y-score (partner→AQP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.728	-3.321	<.001	.010	3	2
UCEC	ACC1 →	+0.384	+2.459	.028	.020	2	2
UCEC	MEK1 →	+0.515	+3.321	.003	.010	3	1
UCEC	MSH6 →	-0.633	-2.459	<.001	.020	3	1
UCEC	Notch1 →	+0.265	+3.331	<.001	.005	3	1
UCEC	Rab25 →	-0.385	-3.000	.016	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

p38-MAPK_pT180_Y182 by AQP3 expression — UCEC

Explore this box plot interactively →