AQP2

Across TCGA patient cohorts, AQP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,913 significant associations in total. THCA shows the largest number of these associations.

The most reproducible AQP2-associated GO terms across cancer lineages are Response to water deprivation, Hypotonic response, and Respiratory system development. Each is linked with AQP2 in more than 14 cancer types. Because this analysis shows association rather than direction, both AQP2-to-partner and partner-to-AQP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to water deprivation grouped by AQP2-low versus AQP2-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP2→partner) and Y-score (partner→AQP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Response to water deprivation →	-0.110	-0.889	<.001	<.001	3	15
UCS	Hypotonic response →	+0.071	+0.442	<.001	<.001	3	14
STAD	Respiratory system development →	+0.029	+0.484	<.001	.001	2	14
PAAD	Cellular hypotonic response →	+0.084	+0.487	<.001	<.001	3	13
KICH	Cellular response to water stimulus →	-0.072	-0.682	<.001	.001	3	13
ESCA	Negative regulation of protein polymerization →	+0.049	+0.711	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,913 associations by consensus.

Response to water deprivation by AQP2 expression — ESCA

Explore this box plot interactively →