AQP2

Across TCGA patient cohorts, AQP2 protein abundance is significantly associated with the RNA expression of many other genes, with 1,051 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible AQP2-associated genes across cancer lineages are CCDC134, HMGXB4, and THOC5. Each is linked with AQP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP2-to-partner and partner-to-AQP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AQP2 versus CCDC134 in CCRCC, with a Pearson correlation of -0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP2→partner) and Y-score (partner→AQP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CCDC134 →	-0.313	-0.652	.005	.003	3	1
CCRCC	HMGXB4 →	-0.288	-0.681	<.001	<.001	3	1
CCRCC	THOC5 →	-0.366	-0.848	<.001	<.001	3	1
CCRCC	IFT27 →	-0.349	-0.785	<.001	.001	3	1
CCRCC	SLC25A17 →	-0.182	-0.534	.008	.002	3	1
CCRCC	POLE2 →	-0.431	-0.607	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,051 associations by consensus.

AQP2 vs CCDC134 — CCRCC

Explore this scatter interactively →