AQP2

Across TCGA patient cohorts, AQP2 mutation is significantly associated with the RNA expression of many other genes, with 138 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible AQP2-associated genes across cancer lineages are RNA5SP457, RNU6-973P, and SNORD31B. Each is linked with AQP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP2-to-partner and partner-to-AQP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP457 grouped by AQP2-low versus AQP2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP2→partner) and Y-score (partner→AQP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP457 →	+0.312	+4.758	.003	.003	3	2
BLCA	RNU6-973P →	+0.300	+5.018	<.001	.004	3	2
BLCA	SNORD31B →	+0.364	+5.147	<.001	.003	3	2
SKCM	MIR645 →	+0.541	+3.812	.007	.005	3	2
CESC	RNA5SP420 →	+0.161	+5.579	<.001	.001	3	2
BLCA	RPS6P14 →	+0.041	+4.588	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 138 associations by consensus.

RNA5SP457 by AQP2 expression — BLCA

Explore this box plot interactively →