AQP2

Across TCGA cell cohorts, AQP2 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible AQP2-associated genes across cancer lineages are OR1L1 and OR2T6. Each is linked with AQP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP2-to-partner and partner-to-AQP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L1 grouped by AQP2-low versus AQP2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP2→partner) and Y-score (partner→AQP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR1L1 →	+0.022	+5.196	<.001	.005	3	1
OVARY	OR2T6 →	+0.052	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

OR1L1 by AQP2 expression — OVARY

Explore this box plot interactively →