Across TCGA pan-cancer cohorts, AQP12B Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated AQP12B data layer compared with 17 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher AQP12B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated AQP12B expression acts as an unfavorable survival marker.

LUSC and SKCM are the cancer types where AQP12B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.001	0.762	<.001	42	view →
SKCM	OS	Median	III,IV	0.179	0.721	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: AQP12B tumor-vs-normal RNA expression · all AQP12B data types