AQP10

Across TCGA pan-cancer cohorts, AQP10 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated AQP10 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher AQP10 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated AQP10 expression acts as an unfavorable survival marker.

SCLC, STAD, and BLCA are the cancer types where AQP10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.082	0.708	<.001	36	view →
STAD	DFS	Median	III,IV	0.142	0.592	<.001	28	view →
BLCA	OS	Median	All	0.174	0.722	<.001	24	view →
LUSC	DFS	Median	All	0.079	0.792	<.001	24	view →
UCEC	OS	Median	IV	0.225	0.772	<.001	12	view →
SKCM	DFS	Median	III,IV	0.063	0.648	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

AQP10–SCLC (OS)

Open the SCLC breakdown →