AQP1

Across TCGA patient cohorts, AQP1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AQP1-associated genes across cancer lineages are VHL, JNK2, and Rad50. Each is linked with AQP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP1-to-partner and partner-to-AQP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by AQP1-low versus AQP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP1→partner) and Y-score (partner→AQP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.084	-3.321	.002	.010	3	2
UCEC	JNK2 →	+0.262	+3.009	.011	.019	3	1
UCEC	Rad50 →	-0.305	-2.986	.016	.035	3	1
SKCM	p21 →	-0.684	-3.152	.003	.019	2	1
SKCM	P-Cadherin →	+0.333	+3.000	.015	.035	2	1
SKCM	PDCD4 →	-0.573	-3.169	.008	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

VHL by AQP1 expression — UCEC

Explore this box plot interactively →