APTX

Across TCGA patient cohorts, APTX RNA expression is significantly associated with the mutation status of many other genes, with 9,490 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APTX-associated genes across cancer lineages are TP53, LCT, and TTN. Each is linked with APTX in more than 7 cancer types. Because this analysis shows association rather than direction, both APTX-to-partner and partner-to-APTX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by APTX-low versus APTX-high in GBM.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APTX→partner) and Y-score (partner→APTX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TP53 →	+1.614	+0.216	.001	.009	3	8
COAD	LCT →	+2.155	+0.270	.009	.001	3	6
STAD	TTN →	+0.989	+0.295	<.001	<.001	3	6
STAD	KMT2D →	+1.869	+0.285	<.001	.003	3	6
STAD	MUC16 →	+1.126	+0.281	<.001	<.001	3	6
UCEC	CSMD1 →	+1.462	+0.192	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,490 associations by consensus.

TP53 by APTX expression — GBM

Explore this box plot interactively →