APTX

Across TCGA patient cohorts, APTX protein abundance is significantly associated with the RNA expression of many other genes, with 11,497 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible APTX-associated genes across cancer lineages are RGP1, TOPORS, and EXOSC3. Each is linked with APTX in more than 6 cancer types. Because this analysis shows association rather than direction, both APTX-to-partner and partner-to-APTX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APTX versus RGP1 in LSCC, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APTX→partner) and Y-score (partner→APTX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RGP1 →	+0.597	+0.532	<.001	<.001	3	7
HNSC	TOPORS →	+0.669	+0.335	<.001	<.001	3	7
LSCC	EXOSC3 →	+0.531	+0.298	<.001	<.001	3	6
LSCC	UBAP2 →	+0.786	+0.498	<.001	<.001	3	6
HNSC	ZCCHC7 →	+0.507	+0.289	<.001	<.001	3	6
HNSC	NDUFB6 →	+0.694	+0.246	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,497 associations by consensus.

APTX vs RGP1 — LSCC

Explore this scatter interactively →