APTX

Across TCGA patient cohorts, APTX mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APTX-associated genes across cancer lineages are mTOR_pS2448, FASN, and IGFBP2. Each is linked with APTX in more than 1 cancer types. Because this analysis shows association rather than direction, both APTX-to-partner and partner-to-APTX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by APTX-low versus APTX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APTX→partner) and Y-score (partner→APTX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.156	-2.321	.036	.035	3	2
UCEC	FASN →	+0.420	+2.321	.033	.035	3	1
UCEC	IGFBP2 →	-0.692	-3.000	.034	.036	3	1
UCEC	PKC-delta_pS664 →	-0.153	-2.999	.011	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+0.740	+2.321	.013	.035	3	1
UCEC	c-Met_pY1235 →	+0.090	+3.009	.016	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

mTOR_pS2448 by APTX expression — UCEC

Explore this box plot interactively →