APTX

Across TCGA cell cohorts, APTX mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APTX-associated genes across cancer lineages are OR13C8, GFRA4, and OR2M5. Each is linked with APTX in more than 1 cancer types. Because this analysis shows association rather than direction, both APTX-to-partner and partner-to-APTX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13C8 grouped by APTX-low versus APTX-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APTX→partner) and Y-score (partner→APTX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR13C8 →	+0.027	+4.662	<.001	.005	3	1
LARGE_INTESTINE	GFRA4 →	+0.025	+4.930	<.001	.001	3	1
LARGE_INTESTINE	OR2M5 →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CAPZA3 →	+0.044	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	PPIAL4E →	+0.033	+4.095	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR13C8 by APTX expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →