Across TCGA patient cohorts, APRT mutation is significantly associated with the RNA expression of many other genes, with 160 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APRT-associated genes across cancer lineages are SEC13, DFFA, and CDK5. Each is linked with APRT in more than 1 cancer types. Because this analysis shows association rather than direction, both APRT-to-partner and partner-to-APRT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APRT→partner) and Y-score (partner→APRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC13 →	+0.548	+3.210	.001	.009	3	1
UCEC	DFFA →	+0.609	+3.217	.001	.009	3	1
UCEC	CDK5 →	+0.517	+3.375	.003	.005	3	1
UCEC	CARD19 →	+0.457	+3.242	.008	.009	3	1
UCEC	MVD →	+0.743	+3.354	.002	.005	3	1
UCEC	CHAF1A →	+0.857	+3.343	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 160 associations by consensus.

Exploration

APRT survival (RNA) · tumor vs normal (RNA) · all APRT data types