APRT

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, APRT mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APRT-associated genes across cancer lineages are ARID1A, ASNS, and ERK2. Each is linked with APRT in more than 1 cancer types. Because this analysis shows association rather than direction, both APRT-to-partner and partner-to-APRT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APRT→partner) and Y-score (partner→APRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECARID1A →-0.279-2.989.007.03531
UCECASNS →+0.571+3.000.006.03721
UCECERK2 →+0.275+3.000.013.03711
UCECc-Jun_pS73 →-0.225-3.000.014.03711
Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration