APPL2

Across TCGA patient cohorts, APPL2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APPL2-associated genes across cancer lineages are GAPDH, Rad50, and S6_pS240_S244. Each is linked with APPL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both APPL2-to-partner and partner-to-APPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by APPL2-low versus APPL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APPL2→partner) and Y-score (partner→APPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.480	+2.169	.017	.003	3	2
UCEC	Rad50 →	-0.213	-1.765	.019	.014	3	2
UCEC	S6_pS240_S244 →	+0.485	+3.584	.001	.002	3	2
UCEC	ATM →	-0.425	-1.415	.012	.046	3	2
UCEC	c-Kit →	-0.191	-2.662	.029	<.001	3	2
UCEC	c-Myc →	-0.188	-2.000	.041	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

GAPDH by APPL2 expression — UCEC

Explore this box plot interactively →