APPL2

Across TCGA cell cohorts, APPL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,117 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible APPL2-associated GO terms across cancer lineages are Cold acclimation, Adiponectin-activated signaling pathway, and Positive regulation of pinocytosis. Each is linked with APPL2 in more than 19 cancer types. Because this analysis shows association rather than direction, both APPL2-to-partner and partner-to-APPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cold acclimation grouped by APPL2-low versus APPL2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APPL2→partner) and Y-score (partner→APPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Cold acclimation →	+0.240	+1.459	<.001	<.001	3	20
STOMACH	Adiponectin-activated signaling pathway →	+0.150	+1.077	<.001	<.001	3	20
BLOOD_Leukemia	Positive regulation of pinocytosis →	+0.169	+1.255	<.001	<.001	3	19
STOMACH	Protein localization to lysosome →	+0.092	+1.107	.003	.002	3	15
UPPER_AERODIGESTIVE_TRACT	Protein targeting to lysosome →	+0.093	+0.867	<.001	.002	3	14
KIDNEY	Protein targeting to vacuole →	+0.073	+0.717	<.001	.002	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,117 associations by consensus.

Cold acclimation by APPL2 expression — STOMACH

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