APPL2

Across TCGA cell cohorts, APPL2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APPL2-associated genes across cancer lineages are SLC32A1, GALNTL5, and TEX55. Each is linked with APPL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both APPL2-to-partner and partner-to-APPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC32A1 grouped by APPL2-low versus APPL2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APPL2→partner) and Y-score (partner→APPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SLC32A1 →	+0.016	+5.087	<.001	.004	3	1
URINARY_TRACT	GALNTL5 →	+0.049	+5.087	<.001	.004	3	1
CNS	TEX55 →	+0.049	+5.321	<.001	.005	3	1
CNS	HES3 →	+0.041	+5.321	<.001	.005	3	1
CNS	OR11H6 →	+0.021	+5.321	<.001	.005	3	1
CNS	FGF3 →	+0.040	+4.981	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

SLC32A1 by APPL2 expression — URINARY_TRACT

Explore this box plot interactively →