APPL1

Across TCGA patient cohorts, APPL1 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,887 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible APPL1-associated proteins across cancer lineages are QRICH1, COPB2, and TOP2B. Each is linked with APPL1 in more than 6 cancer types. Because this analysis shows association rather than direction, both APPL1-to-partner and partner-to-APPL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APPL1 versus QRICH1 in GBM, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (APPL1→partner) and Y-score (partner→APPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	QRICH1 →	+0.199	+0.374	<.001	<.001	3	7
LUAD	COPB2 →	-0.204	-0.269	<.001	<.001	3	5
HNSC	TOP2B →	+0.368	+0.631	<.001	<.001	2	6
BRCA	KIAA1143 →	+0.378	+0.523	<.001	<.001	3	5
LSCC	ZMYM2 →	+0.287	+0.309	<.001	<.001	3	4
BRCA	OSBPL3_S304 →	-0.753	-0.625	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,887 associations by consensus.

APPL1 vs QRICH1 — GBM

Explore this scatter interactively →